Synthesis and in-vitro antimicrobial screening of 3-cinnamoyl coumarin and 3-[3-(1H-indol-2-yl)-3-aryl-propanoyl]-2H-chromen-2-ones
نویسندگان
چکیده مقاله:
An efficient synthesis of some novel coumarin derivatives via 1, 4- Michael addition of indole to coumarin chalcones catalyzed by cellulose sulphonic acid (CSA) under solvent free conditions is described. The corresponding Michael addition products were obtained in good to excellent yield. The synthesized compounds were screened for their antibacterial activity against E. coli, S. aureus and anti-fungal activity against C. albicans. All the synthesized compounds show moderate to good antimicrobial activity.
منابع مشابه
synthesis and in-vitro antimicrobial screening of 3-cinnamoyl coumarin and 3-[3-(1h-indol-2-yl)-3-aryl-propanoyl]-2h-chromen-2-ones
an efficient synthesis of some novel coumarin derivatives via 1, 4- michael addition of indole to coumarin chalcones catalyzed by cellulose sulphonic acid (csa) under solvent free conditions is described. the corresponding michael addition products were obtained in good to excellent yield. the synthesized compounds were screened for their antibacterial activity against e. coli, s. aureus and an...
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عنوان ژورنال
دوره 3 شماره 3
صفحات 171- 176
تاریخ انتشار 2013-09-01
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